Rafael Pena-Miller

Publications

• Antibiotic Cycling and Antibiotic Mixing: which one best mitigates antibiotic resistance?
  R. E. Beardmore, R. Pena-Miller, F. Gori and J. Iredell
  Molecular Biology and Evolution, msw292 (2017).
  
  ↑ We wrote a blog in The Conversation about this article
  
• Using a sequential regimen to eliminate bacteria at sublethal antibiotic dosages
  Ayari Fuentes-Hernandez, Jessica Plucain, Fabio Gori, Rafael Peña-Miller, Carlos Reding, Gunther Jansen, Hinrich Schulenburg, Ivana Gudelj and Robert Beardmore
  PLoS Biology, Vol. 13, No. 4, e1002104 (2015).
  
  ↑ Highlighted in PLoS Biology: Alternating Antibiotics Render Resistant Bacteria Beatable.
     For other Twitter and Media coverage see this Storify
  
• Evaluating the effect of horizontal transmission on the stability of plasmids under different selection regimes
  Rafael Peña-Miller, Rogelio Rodriguez-Gonzalez, Craig MacLean and Alvaro San Millan
  Mobile Genetic Elements, Vol. 5, No. 3 (2015).
• Positive selection and compensatory adaptation interact to stabilize non-transmissible plasmids
  Alvaro San Millan, Rafael Peña-Miller, Macarena Toll-Riera, Zoe Halbert, Angela McLean, Ben Cooper and Craig MacLean
  Nature Communications, Vol. 5, No. 5208 (2014).
  
  ↑ Highlighted in Nature Reviews Microbiology: How to keep your plasmids.
  
• Bistable expression of virulence genes in Salmonella leads to the formation of an antibiotic-tolerant subpopulation
  Markus Arnoldini, Ima Avalos Vizcarra, Rafael Peña-Miller, Nicolas Stocker, M. Diard, V. Vogel, Robert Beardmore, Wolf-Dietrich Hardt, Martin Ackermann
  PLoS Biology, Vol. 12, No. 8 (2014).
  
  ↑ Highlighted in PLoS Biology: Bugs Split to Attack and Gamble to Survive
  
• Testing the optimality properties of a dual antibiotic treatment in a two-locus, two-allele model
  Rafael Peña-Miller, Ayari Fuentes-Hernandez, Carlos Reding, Ivana Gudelj, Robert Beardmore
  Journal of the Royal Society Interface, Vol. 11, No. 96 (2014).
• Genomics of rapid adaptation to antibiotics: convergent evolution and scalable sequence amplification
  David Laehnemann, Rafael Peña-Miller, Philip Rosenstiel, Robert Beardmore, Gunther Jansen, Hinrich Schulenburg
  Genome biology and evolution, evu106 (2014).
• When the most potent combination of antibiotics selects for the greatest bacterial load: the smile-frown transition
  Rafael Peña-Miller, David Lahnemann, Gunther Jansen, Ayari Fuentes-Hernandez, Philip Rosenthiel, Hinrich Schulemburg and Robert Beardmore
  PLoS Biology, Vol. 11, No. 4, e1001540 (2013).
  
  ↑ Highlighted in Nature Reviews Microbiology: When synergism back-fires and in Evolutionary Applications
     Press coverage: New Scientist, Science Now, Science podcast, Science Daily, German RTL
  
• Selecting against drug-resistant pathogens: optimal treatments in the presence of commensal bacteria
  ← Winner of the Lee Segel Prize
  
  Rafael Peña-Miller, David Lahnemann, Hinrich Schulemburg, Martin Ackermann and Robert Beardmore
  Bulletin of Mathematical Biology, Vol. 74, No. 4, pp. 908-943 (2011)

ALL PUBLICATIONS »
Google Scholar Profile »
The optimal deployment of synergistic antibiotics: a control-theoretic approach
← Recommended in F1000

Rafael Peña-Miller, David Lahnemann, Hinrich Schulemburg, Martin Ackermann and Robert Beardmore
Journal of the Royal Society Interface, Vol. 9, No. 75 pp. 2488-502 (2012)
Controlling the evolution of antibiotic resistance
Rafael Peña-Miller
PhD Thesis, Imperial College London (2011).
Single-cell time-lapse analysis of depletion of the universally conserved essential protein YgjD
← BioMed Central Highly Accessed

Tobias Bergmiller, Rafael Peña-Miller, Alex Boehm, Martin Ackermann.
BMC Microbiology, Vol. 11, No. 118 (2011).
Antibiotic cycling versus mixing: the difficulty of using mathematical models to definitively quantify their relative merits
Robert Beardmore, Rafael Peña-Miller
Mathematical Biosciences and Engineering, Vol. 7, No. 4, pp. 923-933 (2010).
Rotating antibiotics selects optimally against antibiotic resistance, in theory
Robert Beardmore, Rafael Peña-Miller
Mathematical Biosciences and Engineering, Vol 7, No. 3, pp. 527-552 (2010).
Modelling cognitive decline in the Hypertension in the Very Elderly Trial [HYVET] and proposed risk tables for population use
Peters R, Beckett N, Beardmore R, Peña-Miller R, Rockwood K, Mitnitski A, Mt-Isa S, Bulpitt C.
PLoS One, volume 5, no. 7 (2010).
Strömgren uvby-β photoelectric photometry of the variable stars RU PSC, SS PSC and TU UMa
JH Peña, R Figuera Jaimes, M Chow, R. Peña-Miller, M. Alavarez.
RevMexAA, vol 48, No. 2, pp. 299–303, (2012).
uvby-β photoelectric photometry of Cepheid stars
J. H. Peña, A. Arellano-Ferro, R. Peña-Miller, M. Alavarez, Y. Rosas, H. Garcia, G. Muñoz, B. Vargas, J.P. Sareyan, C.A. Guerrero and A. Renteria.
RevMexAA, vol 46, No. 2, pp. 291–308, (2010).
Physical Parameters of seven field RR Lyrae stars in Bootes
J.H. Peña, A. Arellano Ferro, R. Peña Miller, J.P. Sareyan and M. Alvarez.
RevMexAA, vol 45, No. 2, pp. 191-204, (2009).
D115520, a new δ Scuti Star
J. H Peña, J. P Sareyan, B. Cervantes-Sodi, R. Peña-Miller, M. Álvarez, M. Cano y M. Sorcia.
RevMexAA vol. 43, No. 1, pp. 217-224 (2007).

« SELECTED PUBLICATIONS
Google Scholar Profile »